Background: Keloid scarring is a dermal fibroproliferative disorder characterized by increased fibroblast proliferation and excessive production of collagen-extracellular matrix (ECM) components. To date, the role of cytokines in the keloid pathogenesis has not been completely unraveled. Interleukin-18 (IL-18) is a pro-inflammatory cytokine that plays important roles in wound healing, fibrogenesis and carcinogenesis, and our aim was to study the role of IL-18 sytem in keloid pathogenesis.
Methods and Findings: Results from Western blot and immunohistochemistry revealed that IL-18, IL-18Rα and IL-18Rβ expression were elevated in keloid tissue compared with normal skin ...
Interleukin-18 system plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions is a post from: Skincare
Interleukin-18 system plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions via BuzzBlazer.com
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