Compound Astragalus and Salvia miltiorrhiza Extract Inhibits Cell Proliferation, Invasion and Collagen Synthesis in Keloid Fibroblasts by Mediating TGF-beta/Smad Pathway

Summary

Background  Transforming growth factor beta (TGF-β)/Smad pathway plays a key role in keloid development. We have previously demonstrated that Compound Astragalus and Salvia miltiorrhiza Extract (CASE) inhibits liver fibrosis and reduces invasion capacity of HepG2 cells by mediating TGF-β/Smad pathway. We therefore hypothesize that CASE may also exert anti-fibrosis effects in keloids by mediating TGF-β/Smad pathway.


Objectives  To investigate the effects of CASE on cell proliferation, invasion and collagen synthesis in keloid fibroblasts and further elucidate its action mechanisms involved in TGF-β/Smad pathway.


Methods  The inhibitory effects of CASE on keloid fibroblasts ...

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