Cutaneous adverse drug reactions to allopurinol: 10 year observational survey of the dermatology department – cagliari university (Italy)

Abstract

Background  Allopurinol is extensively prescribed for conditions associated with urate excess, despite being responsible for severe cutaneous adverse drug reactions (ADR).


Objective  A cross-sectional survey of allopurinol cases observed at the main Dermatology Department with inpatients facilities in southern Sardinia. (approx 560 836 inhabitants).


Material and methods  Data collection of all consecutive patients referred for ADR between 2001 and 2010. Causality assessment followed the WHO Collaborating Centre for Drug Monitoring criteria; illness severity score was adopted for toxic epidermal necrolysis (SCORTEN).


Results  Allopurinol was the culprit drug in 84 of 780 cutaneous ADR cases ...

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