Psoriasis and psoriatic arthritis are treated very efficaciously with infliximab, a chimaeric human-murine anti-tumor necrosis factor alpha (TNF-α) antibody. As we reported earlier, infliximab, besides its anti-inflammatory properties, induces a caspase-independent programmed cell death of psoriatic keratinocytes. In order to further elucidate this finding, we investigated the epidermal expression of proteins involved in the mitochondria-dependent (intrinsic) pathway of cell death. Quantification of proteins with pro- (p53, AIF, Bax) and anti-apoptotic functions (Bcl-2, Bcl-XL) and of NF-κB was performed by means of immunohistochemistry and digital image analysis of the staining of ...
Infliximab restores the balance between pro- and anti-apoptotic proteins in regressing psoriatic lesions is a post from: Skincare
Infliximab restores the balance between pro- and anti-apoptotic proteins in regressing psoriatic lesions via BuzzBlazer.com
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