Thursday, February 17, 2011

A novel technique for chitosan microparticle preparation using a water/silicone emulsion: green tea model

Synopsis

Many effective methods such as spray drying, coacervation, ionic gelation, solvent evaporation and sieving have been suggested for entrapping bioactive compounds into micro- or nanoparticles. However, those methods still have some limitations owing to high temperature requirement, difficulty in particle harvesting or low entrapment for uncharged molecules. In this study, a novel chitosan microparticle preparation method was developed using water-in-silicone emulsion technique with green tea extract as a model active compound. Chitosan microparticles of diameter <5 μm were obtained from 2% chitosan solution with tripolyphosphate (TPP) solution as the hardening agent. ...

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