Elevated levels of TNF-α, IL-1β and IL-10 in hidradenitis suppurativa skin; a rationale for targeting TNF-α and IL-1β

Summary

Background:  The pathogenesis of hidradenitis suppurativa (HS) is largely unknown and the disease is difficult to treat. Patients are in high need of an effective treatment. Although it is not known whether the levels of TNF-α are aberrant in HS skin, anti-TNF-α biologics are used, with variable clinical efficacy.


Objectives:  To determine the cytokine profile in lesional and perilesional HS skin.


Methods:  We cultured 20 lesional, 10 normal appearing perilesional HS skin samples, 7 psoriasis and 6 healthy control skin samples in a transwell culture system. Two distinct cytokine bead arrays were ...

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