BRM and BRG1 subunits of the SWI/SNF chromatin-remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours

Abstract

Background  Non-melanoma skin cancer is caused by exposure to ultraviolet radiation within sunlight. Actinic keratoses (AK) are benign precursor lesions that can develop into invasive squamous cell carcinoma (SCC). Little is known about the molecular events that lead to human skin cancer progression from benign to invasive.


Objectives  To determine novel genes that may be involved in skin cancer progression based on data from an initial microarray screen of human skin cancers.


Methods  The SWI/SNF chromatin remodelling ATPase subunit BRM was identified as being downregulated in SCC but not AK compared to ...

BRM and BRG1 subunits of the SWI/SNF chromatin-remodelling complex are downregulated upon progression of benign skin lesions into invasive tumours is a post from: Skincare

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