Objective: To investigate the histological classification of melasma with reflectance confocal microscopy (RCM) in vivo.
Methods: Two hundred and ten cases with facial melasma lesions were enrolled. After informed consent, the target melasma lesion of 10 patients were imaged with RCM and then biopsied as well. Under the RCM scanning, the distribution of the melanin determined the histological types, and then, the results of RCM images were compared with those of the histopathology. The other 200 cases were tested only with RCM.
Results: For the 10 cases imaged and ...
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