Altered Expression of Co-stimulatory Molecules in Behçet’s Disease According to Clinical Activity

Abstract

Background:  The reduced expression of molecules limiting excessive immune responses has been considered a pathogenic mechanism associated with autoimmune diseases.


Objectives:  To understand the implications of co-stimulatory molecules in Behçet’s disease (BD), the expression of CTLA-4 and PD-1 on T cell subsets and of their ligands, CD80, CD86 and PD-L1 on antigen presenting cells (APCs) were investigated.


Methods:  The mononuclear blood cells of subjects (11 patients with active BD, 8 patients with inactive BD, 8 patients with recurrent aphthous ulcers and 10 healthy volunteers as healthy controls (HC)) were stimulated with PMA ...

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