Topical ALA-PDT produces an inflammatory infiltrate but reduces Langerhans cells in healthy human skin in vivo

Summary

Background:  Topical photodynamic therapy (PDT) elicits a therapeutic response in both skin cancer and immune-mediated skin disorders. While PDT induces direct cell death, host inflammatory and immune responses to PDT may contribute to the therapeutic effects.


Objectives:  To examine the impact of topical PDT on leucocyte trafficking and mediators of chemotaxis in healthy human skin.


Methods:  Aminolevulinic acid (ALA)-PDT was performed on the buttock skin of 7 healthy volunteers. Biopsies for immunohistochemical assessment were taken 1, 4 and 24 h post-PDT and from untreated contralateral buttock skin (baseline).


Results:  A significant dermal neutrophilic ...

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