Extreme patch test reactivity to p-phenylenediamine but not to other allergens in children

Background. According to clinical impression, extreme patch test reactions (+++) to p-phenylenediamine (PPD) are not uncommon in children.


Objectives. To investigate the patch test reactivity in children (aged 1–14 years) in comparison with other age groups and other allergens.


Methods. A retrospective analysis was performed of data from the German Information Network of Departments of Dermatology, including all patients consecutively patch tested between 1994 and 2004 with PPD, and, for comparison, nickel, fragrance mix I, and methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI). The distribution of +, ++ and +++ grades of positive reactions among those ...

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