Ability to estimate relative percutaneous penetration via a surrogate maker – trans epidermal water loss?

Aims: This study measures the dynamic change of the trans-epidermal water loss (TEWL) rate and in vitro skin permeation data of tritiated water and [14C]-clonidine HCl in order to refine our knowledge in the relationship between percutaneous penetration and TEWL.


Measures: TEWL values were measured before and during the experimental period. Single application of tritiated water and [14C]-clonidine HCl were dosed at the same time on dermatomed human skin samples collected from 12 donors in a flow through diffusion cell system. Radioactivity of absorbed dose: stratum corneum, epidermis, dermis, ...

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