Tuesday, May 17, 2011

Long-Term Treatment of Glabellar Rhytides Using OnabotulinumtoxinA


OBJECTIVE
To determine whether injection every 4 months with onabotulinumtoxinA provides longer-lasting reduction or elimination of glabellar rhytides.


METHODS
Toxin-naive women (N=45) aged 30 to 50 with moderate to severe glabellar lines at maximum contraction completed the study. Five sites were treated with 4 U of onabotulinumtoxinA. Participants were assessed at day 30; those with glabellar severity of none to mild remained in the study. Participants received identical treatments at months 4, 8, 12, 16, and 20, and were assessed without treatment at 24, 25, and 26 months.


RESULTS
Baseline physician- and participant-rated ...

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