Background Keloids or hypertrophic scars are pathologic proliferations of the dermal skin layer resulting from excessive collagen deposition. Because the hormone relaxin (RLX) inhibits collagen synthesis and expression in stimulated fibroblasts, an adenovirus expressing RLX (dE1-RGD/lacZ/RLX) was generated.
Objectives To investigate the effect of relaxin-expressing adenovirus on expression of various extracellular matrixes in primary keloid spheroids.
Methods The expression levels of type I and III collagen, fibronectin, and elastin were investigated by immunohistochemistry in primary keloid spheroids transduced with the RLX-expressing adenovirus.
Results Immunohistochemical analysis showed that expression of major extracellular matrix (ECM) ...
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