Immunophenotype of skin lymphocytic infiltrate in M.leprae and HIV co-infected patients: a scenario dependent of CD8+ and/or CD20+ cells.

Abstract

Background.  Leprosy occurs rarely in human immunodeficiency virus (HIV) positive patients. As opposed to tuberculosis, neither an increase in HIV prevalence among leprosy patients nor differences in leprosy’s clinical spectrum has been reported so far. While several studies describe the systemic immune response profile in HIV-leprosy co-infected patients, local immune skin response has been only evaluated in a small number of case reports and limited series of patients.


Patients and methods.  We investigated the presence and frequency of CD4, CD8, CD20, TIA-1, FoxP3 and CD123 positive cells in lymphocytic infiltrates from ...

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