High-concentration all-trans retinoic acid induces dermal inflammation, and reduces the accumulation of type I procollagen in human skin in vivo

Abstract


Background

Because inflammation is an aging-promoting factor, all-trans-retinoic acid (RA)-induced irritation may have a negative influence on collagen accumulation in human skin despite its stimulation of collagen production.



Objectives

To determine whether RA-induced irritation detrimentally affects RA efficacy representing as new collagen synthesis.



Method

RA (0.01%, 0.025% or 0.05%) or vehicle were applied to the buttock skin of elderly male volunteers 3 times a week for 8 weeks under continuous occlusion. Every 2 weeks, biopsy specimens were obtained and immunohistochemical analysis was performed to determine levels of type I procollagen expression and inflammatory cell infiltration.



Results

Topical ...

High-concentration all-trans retinoic acid induces dermal inflammation, and reduces the accumulation of type I procollagen in human skin in vivo is a post from: Skincare

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