Randomized double-blinded placebo-controlled intra-individual trial on 1,25-(OH)2 vitamin D3 analogue in polymorphic light eruption

Summary

Background:  Polymorphic light eruption (PLE) is very frequent photodermatosis whose pathogenesis may involve resistance to UV-induced immune suppression. Similar to UV radiation, calcitriol (1,25-(OH) vitamin D3) and its analogues such as calcipotriol have been shown to exhibit immunosuppressive properties.


Methods:  We performed a randomized double-blinded placebo-controlled intra-individual half-body trial (NCT00871052) to investigate the preventive effect of a calcipotriol-containing cream in PLE. Thirteen PLE patients (10 women, 3 men; mean age, 37 years) pre-treated their skin on two symmetrically located test fields with calcipotriol or placebo cream twice daily for seven days ...

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