Decorin Expression with Stump Recurrence and Neovascularization after Varicose Vein Surgery—a Pilot Study

BACKGROUND
An evaluation of the reason for saphenofemoral recurrence (SFR, technical error vs neovascularization) after surgery is necessary to improve the method or find purchase for new therapies. Currently, differentiation by the surgeon or ultrasound are unsatisfying; histology depends mainly on the physician’s experience. Decorin, an extracellular matrix component, is up-regulated in angiogenesis with antiangiogenetic effects on neovascularization.


OBJECTIVE
To determine whether decorin is a reliable marker to distinguish neovascularization and stump recurrence.


METHODS
Twenty specimens obtained in re-operation of patients with duplex-detected SFR were stained with hematoxylin and eosin, Elastica van ...

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