Wednesday, March 30, 2011

Immunohistochemical Staining with Melan-A of Uninvolved Sun-Damaged Skin Shows Features Characteristic of Lentigo Maligna


BACKGROUND
The greater density and unusual patterning of melanocytes in chronically sun-exposed skin complicates interpretation of intraoperative Melan-A immunohistochemical stained margins during margin-controlled surgery for lentigo maligna (LM) and lentigo maligna melanoma (LMM).


OBJECTIVE
To identify the immunohistochemical similarities and differences in melanocyte distribution between LM and LMM and chronically sun-exposed skin.


METHODS
Retrospective review of Melan-A-stained original biopsy specimens of LM and LMM and uninvolved sun-damaged skin (negative controls), from 70 LM and LMM cases from the University of Utah in 2008.


RESULTS
Histologic features commonly associated with LM were common in ...

Immunohistochemical Staining with Melan-A of Uninvolved Sun-Damaged Skin Shows Features Characteristic of Lentigo Maligna is a post from: Skincare




Immunohistochemical Staining with Melan-A of Uninvolved Sun-Damaged Skin Shows Features Characteristic of Lentigo Maligna via BuzzBlazer.com

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