Monday, March 28, 2011

Patterns of aluminum hydroxychloride deposition onto the skin


Background: Aluminum hydroxychloride (AlCl3) is an antiperspirant.


Aim: To revisit the AlCl3 deposition in vivo and in vitro on glass slides and stratum corneum (SC) harvested by cyanoacrylate skin surface strippings (CSSS).


Methods: Transepidermal water loss (TEWL) was assessed following application of 5% AlCl3 on the forearms. The AlCl3-coated skin, glass slides and CSSS were observed using two ultraviolet light-emitting CCD cameras in order to record changes in specular reflectance related to AlCl3 deposition. In addition, the corneoxenometry bioassay was performed in order to predict AlCl3 irritation.


Results: AlCl3 ...

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