Background With increasing age the immune system shows functional decline. In the skin this is associated with an increased incidence of epidermal malignancies and infections. Epidermal Langerhans’ cells (LC) act as sentinels of the immune system recognising, processing and presenting antigen and inducing T cell responses. Previous investigations have demonstrated a reduction in the number of epidermal LC in elderly subjects. Moreover, the ability of LC to migrate in response to tumour necrosis factor (TNF)-α, but not interleukin (IL)-1β, is significantly impaired in the elderly.
Objectives To characterise further the changes ...
The effect of ageing on phenotype and function of monocyte derived Langerhans’ cells is a post from: Skincare
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