Wednesday, March 30, 2011

Influence of Aqueous Cream on corneocyte size, maturity, skin protease activity, protein content and Trans-Epidermal Water Loss

Summary

Background:  Aqueous cream B.P. is frequently prescribed for patients with eczema and is known to induce sensitivity in certain patients and also to decrease the thickness of the stratum corneum. We have previously reported methodology to quantify corneocyte maturity and size, protease activity and protein content within different levels of the stratum corneum.


Objectives:  The aim of the present study was to investigate changes in corneocyte size, corneocyte maturity, selected protease activities, protein content and Trans-epidermal water loss (TEWL) in normal skin after a 28-day application of Aqueous Cream B.P.


Methods:  The ...

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