Lack of evidence for a protective effect of prolonged breastfeeding on childhood eczema: lessons from the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two

Summary

Background:  Exclusive breastfeeding for at least 4 months is recommended by many governments and allergy organizations to prevent allergic disease.


Objectives:  To investigate whether exclusive breastfeeding protects against childhood eczema.


Methods:  Study subjects comprised 51 119 randomly selected 8- to 12-year-old schoolchildren in 21 countries. Information on eczema and breastfeeding was gathered by parental questionnaire. Children were also examined for flexural eczema and underwent skin prick testing. Odds ratios (ORs) were calculated for each study centre and then pooled across populations.


Results:  There was a small increase in the risk of reported ‘eczema ever’ ...

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