Acral lesions of vitiligo: why are they resistant to photochemotherapy?

Abstract

Background  Acral lesions of vitiligo are usually resistant to conventional lines of treatment as well as surgical interventions.


Objective  To clarify causes underlying resistance of acral lesions to pigmentation in vitiligo by studying some of the factors associated with mechanisms of repigmentation following photochemotherapy.


Methods  The study included twenty patients with active vitiligo. Skin biopsies were taken from lesional and perilesional skin of areas expected to respond (trunk and proximal limb) and skin of acral areas, before and after PUVA therapy. Sections were stained with H and E, Melan-A, MHCII, CD1a, SCF ...

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