Thursday, August 25, 2011

Assessment of melanocytic skin lesions with a high-definition laser Doppler imaging system


Background

Early detection is a major goal in the management of malignant melanoma. Besides clinical assessment many noninvasive technologies such as dermoscopy, digital dermoscopy and in vivo laser scanner microscopy are used as additional methods. Herein we tested a system to assess lesional perfusion as a tool for early melanoma detection.



Methods

Laser Doppler flow (FluxExplorer) and mole analyser (MA) score (FotoFinder) were applied to histologically verified melanocytic nevi (33) and malignant melanomas (12).



Results

Mean perfusion and MA scores were significantly increased in melanoma compared to nevi. However, applying an empirically determined threshold of ...

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