Background: Vitiligo is a frequently acquired, hereditary disease, characterized by achromic macules due to the absence of melanocytes. In contrast with earlier studies, in which the main pathogenic role was attributed to anti-melanocyte antibodies, recent papers have emphasized a role for CD8+ cytotoxic T lymphocytes in melanocyte destruction. Fifteen percent of peripheral T cell express cutaneous lymphocyte-associated antigen (CLA), responsible for skin-homing T cell. Phototherapy is used to treat patients with generalized vitiligo and it has been shown to interfere with CLA+ T cells in other skin diseases.
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Reduction of skin-homing cytotoxic T cells (CD8+–CLA+) in patients with vitiligo is a post from: Skincare
Reduction of skin-homing cytotoxic T cells (CD8+–CLA+) in patients with vitiligo via BuzzBlazer.com
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