Background The barrier function of the skin may be characterised by a number of biophysical and molecular methods. Variation in the barrier properties as a function of depth has not been explored in detail.
Objectives The aim of the present study was to characterise changes in corneocyte surface area, corneocyte maturity, selected protease activities and Trans-epidermal water loss (TEWL) in the ventral forearm with increasing depth.
Methods The left mid-ventral forearm of 22 healthy volunteers was selected as the study site. After tape-stripping, corneocyte maturity and surface area were assessed. The protease ...
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