Instrumental analysis of the pattern of improvement and that of recurrence of melasma in Thai females treated with Kligman–Willis triple combination therapy: confirmation by using its two different formulae

Background: Melasma is common among females. At present, its most reliable topical treatment is the Kligman–Willis formula.


Objectives: To evaluate objectively the pattern of pigmentation improvement and recurrence.


Methods: Thirty-four Thai females with melasma showing similar lesions on both cheeks were randomly assigned to 8-week daily treatment with either one of two different versions of the formula together with strict sun protection. They were objectively evaluated instrumentally with a Mexameter® every 2 weeks, and were followed up for the subsequent 40 weeks.


Results: Thirty of 34 subjects who completed ...

Instrumental analysis of the pattern of improvement and that of recurrence of melasma in Thai females treated with Kligman–Willis triple combination therapy: confirmation by using its two different formulae is a post from: Skincare

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