Filaggrin polymorphism P478S, IgE level, and atopic phenotypes

Summary

Background  Whether environmental exposures may modulate the effect of the skin barrier gene on atopic dermatitis (AD) remains to be elucidated.


Objectives  This study aims to determine whether filaggrin (FLG) variants can serve as a predictor for atopic disorders in Chinese and if allergen exposures may modify the effect of FLG variants on AD by total IgE levels.


Methods  A total of 116 children aged 2 to 5 years with AD and 212 control subjects were analyzed for the FLG variants using DNA sequencing. Multiple logistic regression models were performed to estimate ...

Filaggrin polymorphism P478S, IgE level, and atopic phenotypes is a post from: Skincare

Filaggrin polymorphism P478S, IgE level, and atopic phenotypes via BuzzBlazer.com