Background/purpose: Current Herpes labialis infection treatment by oral, parenteral or topical routes is inefficient. The objective of this study was to investigate the use of iontophoresis for improved topical delivery of acyclovir (ACV) in vivo in hairless rat.
Methods: Iontophoresis was performed for 10 min using a 5% ACV gel formulation. Tape stripping and skin extractions were performed at different time points following treatment for drug quantification in stratum corneum (SC) and underlying skin, respectively.
Results: Fourfold more ACV was detected in the SC immediately following 10-min iontophoresis as compared ...
Acyclovir skin depot characterization following in vivo iontophoretic delivery is a post from: Skincare
Acyclovir skin depot characterization following in vivo iontophoretic delivery via BuzzBlazer.com
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