Preliminary evidence for involvement of the tumour suppressor gene CHD5 in a family with cutaneous melanoma

Summary

Background  Cutaneous melanoma is rapidly increasing in incidence worldwide and approximately 5% of melanomas are hereditary. Deletions in chromosome 1p36 have been detected in melanoma but no candidate melanoma tumour suppressor gene has yet been found in this area. Recently, Bagchi et al have provided strong evidence that CHD5 is a tumour suppressor gene in this region.


Methods  Peripheral blood DNA from 47 melanoma families who do not carry mutations in any of the three currently recognised melanoma genes, 398 patients with sporadic melanoma and 398 geographically matched non melanoma bearing ...

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