Background: Atopic dermatitis (AD) is a recurrent inflammatory skin disease characterized by dominant Th2-cytokine response. Bacillus Calmette-Guerin (BCG) has been used for preventing tuberculosis, and is regarded as a strong Th1 cytokine inducer. Ag85B is a secretory protein present in mycobacterium species that induces Th1 cytokine production.
Objectives: We investigated the effects of combined vaccination of heat-killed BCG (hkBCG) and Mycobacterium kansasii Ag85B in an AD mouse model.
Methods: As AD model, K14 promoter-derived caspase-1 overexpressing mice (KCASP1Tg) were used. The mice received a combination therapy: hkBCG at the 3rd week of ...
Heat-killed BCG and Mycobacterium kansasii Ag85B combined vaccination ameliorates dermatitis in a mouse model of atopic dermatitis by inducing regulatory T cells is a post from: Skincare
Heat-killed BCG and Mycobacterium kansasii Ag85B combined vaccination ameliorates dermatitis in a mouse model of atopic dermatitis by inducing regulatory T cells via BuzzBlazer.com
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