Formation of Fibrosis After Nonablative and Ablative Fractional Laser Therapy

Background

Fractional laser therapy (FLT) has become a widely accepted modality for skin rejuvenation and has also been used in various other skin diseases.



Objective

To observe long-term histologic effects of nonablative and ablative FLT in the treatment of pigment disorders.



Methods

A randomized controlled observer-blinded study was performed in 18 patients with pigment disorders. Two similar test regions were randomized to receive FLT with intermittent topical bleaching or topical bleaching alone. Patients with ashy dermatosis (AD) and postinflammatory hyperpigmentation (PIH) were treated using nonablative 1,550-nm FLT (15 mJ/microbeam, 14–20% coverage), whereas patients with Becker’s nevus ...

Formation of Fibrosis After Nonablative and Ablative Fractional Laser Therapy is a post from: Skincare

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Effect of Curettage After Segmental Phenolization in the Treatment of Onychocryptosis: A Randomized Double-Blind Clinical Trial

Background

Segmental phenolization for the treatment of onychocryptosis has a number of disadvantages, resulting from the cauterization of the tissue, including delayed healing and prolonged drainage. Although one may expect excision or curettage of the cauterized tissue after phenolization to benefit the healing process, these simple procedures have not been suitably studied.



Objective

To examine the effect of curettage primarily on cicatrization or healing time and secondarily on postoperative bleeding.



Materials and Methods

Fifty-one patients (80 feet) with stage I or IIa onychocryptosis according to the classification of Mozena were enrolled in this randomized, double-blind, parallel-group, ...

Effect of Curettage After Segmental Phenolization in the Treatment of Onychocryptosis: A Randomized Double-Blind Clinical Trial is a post from: Skincare

Effect of Curettage After Segmental Phenolization in the Treatment of Onychocryptosis: A Randomized Double-Blind Clinical Trial via BuzzBlazer.com

Second-Intention Healing of Nasal Alar Defects

Second-Intention Healing of Nasal Alar Defects is a post from: Skincare

Second-Intention Healing of Nasal Alar Defects is a post from: Skincare

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Tacrolimus in the Treatment of Chronic and Refractory Late-Onset Immune-Mediated Adverse Effects Related to Silicone Injections

Background

Although currently not authorized in many countries, medical-grade silicone (MGS) injections have been used for 50 years. Sometimes chronic and severe adverse effects refractory to usual therapy other than corticosteroids appear.



Objective

To evaluate the effectiveness of tacrolimus in the treatment of refractory cases of late-onset adverse effects related to MGS injections.



Methods

Case-series study of seven patients with late-onset adverse effects related to MGS injections. Cases had been treated with a mean of six drugs with poor response before low-tacrolimus dose was introduced. Patients who had received MGS injections with immediate adverse effects or ...

Tacrolimus in the Treatment of Chronic and Refractory Late-Onset Immune-Mediated Adverse Effects Related to Silicone Injections is a post from: Skincare

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Clinical Spectrum of Atypical Fibroxanthoma and Undifferentiated Pleomorphic Sarcoma in Solid Organ Transplant Recipients: A Collective Experience

Background

Atypical fibroxanthoma (AFX) and undifferentiated pleomorphic sarcoma (UPS) are uncommon, spindle cell cutaneous malignancies. Solid organ transplant recipients (SOTRs) are immunosuppressed and therefore have a higher incidence of cutaneous malignancies.



Objective

We describe the clinical spectrum of AFX and a more-aggressive, deeper variant, UPS, in SOTRs.



Materials and Methods

A retrospective chart review of AFX and UPS in SOTRs was implemented. Cases from Vanderbilt University, Emory University, Mayo Clinic—Jacksonville, and University of Rochester were included. A literature search included previously published cases.



Results

The average age of SOTRs at time of tumor presentation was younger than ...

Clinical Spectrum of Atypical Fibroxanthoma and Undifferentiated Pleomorphic Sarcoma in Solid Organ Transplant Recipients: A Collective Experience is a post from: Skincare

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Successful treatment of intravascular papillary endothelial hyperplasia (ipeh) by the beta-adrenergic antagonist nebivolol.

Successful treatment of intravascular papillary endothelial hyperplasia (ipeh) by the beta-adrenergic antagonist nebivolol. is a post from: Skincare

Successful treatment of intravascular papillary endothelial hyperplasia (ipeh) by the beta-adrenergic antagonist nebivolol. is a post from: Skincare

Successful treatment of intravascular papillary endothelial hyperplasia (ipeh) by the beta-adrenergic antagonist nebivolol. via BuzzBlazer.com

Clinical, Molecular and Biochemical Characterization of Nine Spanish Families with Conradi-Hünermann-Happle Syndrome: New Insights into CDPX2 With A Comprehensive Review of the Literature

Abstract

Conradi-Hünermann-Happle syndrome (CDPX2, OMIM 302960) is an inherited X-linked dominant variant of chondrodysplasia punctata (CP) which primarily affects the skin, bones and eyes. CDPX2 results from mutations in EBP (emopamil binding protein), and presents with increased levels of sterol precursors 8(9)cholestenol and 8 dehydrocholesterol. We present one of the largest series reported to date, including 13 female patients belonging to nine Spanish families. Patients were studied biochemically using GC-MS, genetically using PCR and in their methylation status using the HUMARA assay. In our cases, there is a clear relationship between ...

Clinical, Molecular and Biochemical Characterization of Nine Spanish Families with Conradi-Hünermann-Happle Syndrome: New Insights into CDPX2 With A Comprehensive Review of the Literature is a post from: Skincare

Clinical, Molecular and Biochemical Characterization of Nine Spanish Families with Conradi-Hünermann-Happle Syndrome: New Insights into CDPX2 With A Comprehensive Review of the Literature via BuzzBlazer.com