The effect of 308 nm excimer laser on segmental vitiligo: a retrospective study of 80 patients with segmental vitiligo

Background: Segmental vitiligo (SV), which frequently accompanies poliosis, indicating a poor prognosis that is likely resistant to treatments.


Objectives: In this study, we performed a retrospective analysis to evaluate the treatment response to 308 nm excimer laser in SV patients.


Methods: A retrospective chart and photographic review was performed on 80 SV patients who had been treated with 308 nm excimer laser for >3 months.


Results: Eighty patients with SV (mean age: 24.0 years ± 15.3, males: 50%) were included in this study. The mean grade of repigmentation was 2.3 after ...

The effect of 308 nm excimer laser on segmental vitiligo: a retrospective study of 80 patients with segmental vitiligo is a post from: Skincare

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Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis

Background: Diallyl sulfide (DAS) has been shown to have a preventive effect against various cancers.


Aims and objectives: We evaluated the protective effects of DAS in regression of ultraviolet B (UVB)-induced skin tumor formation in SKH-1 hairless mice and its underlying early molecular biomarkers.


Methods: We examined the efficacy of DAS in UVB light-induced skin lesion in SKH-1 hairless mice and the associated molecular events.


Results: Mice irradiated with UVB at 180 mJ/cm2 twice per week elicited 100% tumor incidence at 20 weeks. The topical application of DAS before UVB ...

Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis is a post from: Skincare

Diallyl sulfide protects against ultraviolet B-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular events in carcinogenesis via BuzzBlazer.com

The risk to normal and photosensitive individuals from exposure to light from compact fluorescent lamps

Background/purpose: The incandescent electric light bulb has been in widespread use since the early part of the 20th century. There is now a strong move underway to improve lighting efficiency to cut carbon dioxide emissions. As a result, many countries have introduced legislation to phase out the use of incandescent bulbs, and these are largely being replaced with compact fluorescent lamps (CFLs). The rate at which CFLs are replacing the traditional bulbs has caused alarm among patients with light-sensitive skin disorders as there has been very little informed discussion ...

The risk to normal and photosensitive individuals from exposure to light from compact fluorescent lamps is a post from: Skincare

The risk to normal and photosensitive individuals from exposure to light from compact fluorescent lamps via BuzzBlazer.com

Adverse effects of topical photodynamic therapy

Background/purpose: Topical photodynamic therapy (PDT) is increasingly used in dermatology, particularly for the treatment of superficial non-melanoma skin cancer and dysplasia. Treatment is generally considered to be well tolerated, although pain during PDT can be a limiting factor. This review explores the adverse effects of topical PDT.


Methods: A thorough search of the literature using Medline was undertaken and published data were evaluated and presented in conjunction with our own experience.


Results: Pain during PDT is the most commonly reported adverse effect and may prevent successful treatment delivery, although ...

Adverse effects of topical photodynamic therapy is a post from: Skincare

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HIGHLIGHTS FOR JUNE

HIGHLIGHTS FOR JUNE is a post from: Skincare

HIGHLIGHTS FOR JUNE is a post from: Skincare

HIGHLIGHTS FOR JUNE via BuzzBlazer.com

Seemingly healthy skin in atopic dermatitis: observations with the use of high-frequency ultrasonography, preliminary study

Background: Atopic dermatitis (AD) is a chronic, relapsing skin disorder which is strictly determined by the epidermal barrier function. In previous studies, there is conclusive evidence that normal-looking, nonlesional skin presents meaningful barrier function defect and a sub-clinical eczematous skin reaction.


Aim: The authors intended to visualize nonlesional AD skin with the use of high frequency ultrasonography to show that the normal-looking, nonlesional skin may present significant abnormalities in USG examination.


Methods: We have performed analysis with the use of high-frequency 20 MHz skin sonography in the cases of ...

Seemingly healthy skin in atopic dermatitis: observations with the use of high-frequency ultrasonography, preliminary study is a post from: Skincare

Seemingly healthy skin in atopic dermatitis: observations with the use of high-frequency ultrasonography, preliminary study via BuzzBlazer.com

Buffering capacity of human skin layers: in vitro

Background/purpose: The skin possesses buffering capacity to resist acidic/alkaline aggression. Skin components contribute differently to this buffering capacity. This study investigates buffering capacity in three skin layers: intact stratum corneum (SC), epidermis and dermis.


Methods: Sodium hydroxide (NaOH) and hydrochloric acid (HCl) solutions at 0.025, 0.05 and 0.1 N were applied to skin (3.18 μL/cm2). After 30 min, the skin was washed with 1 mL de-ionized water. TEWL and pH measurements were conducted at baseline (before contact with acid or base), 0, 10 and 30 min post exposure, and continued at 0, 10 and ...

Buffering capacity of human skin layers: in vitro is a post from: Skincare

Buffering capacity of human skin layers: in vitro via BuzzBlazer.com