Patient acceptance and diagnostic utility of automated digital image analysis of pigmented skin lesions

Abstract

Background  Computerized analysis of pigmented skin lesions may help to increase diagnostic accuracy for melanoma, help to avoid unnecessary procedures and reduce health care costs.


Objectives  We evaluated both the patient acceptance and diagnostic utility of such an analysis tool in a real clinical setting.


Methods  Two hundred nine consecutive patients (median age: 34 years, range: 2–73 years), who were concerned about a pigmented skin lesion, answered a questionnaire about their attitude towards computerized analysis and their confidence in the resulting findings. Using a dermoscopy analyser, their skin lesions (n = 219) were then grouped into ...

Patient acceptance and diagnostic utility of automated digital image analysis of pigmented skin lesions is a post from: Skincare

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Two noval mutations of nicastrin gene in Chinese patients with Acne inversa

Summary

Background:  Acne inversa (AI), also called hidradenitis suppurativa, is a chronic inflammatory skin disease that usually presents after puberty with painful deep seated, inflamed lesions in the apocrine gland-bearing areas of the body, most commonly the axilla, inguinal and anogenital regions. To date, only one article testified that AI is caused by identified mutations of γ-secretase genes. γ-secretase is a transmembrane protease comprised of four essential protein subunits including presenilin (PSEN1), presenilin enhancer 2 (PSENEN), nicastrin (NCSTN), and anterior pharynx defective 1 (APH1).


Objectives:  To identify mutations of γ-secretase genes as ...

Two noval mutations of nicastrin gene in Chinese patients with Acne inversa is a post from: Skincare

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A case of monilethrix caused by novel compound heterozygous mutations in the desmoglein 4 (DSG4) gene

Summary

Background:  Monilethrix is a rare condition characterized by a hair shaft anomaly known as beaded hair. It can show either an autosomal dominant or recessive inheritance pattern. Autosomal dominant form of monilethrix is caused by mutations in basic hair keratin genes KRT81, KRT83, or KRT86, while autosomal recessive form is resulting from mutations in desmoglein 4 (DSG4) gene.


Objectives:  To define the molecular basis of monilethrix in a Japanese patient who has had sparse and fragile scalp hairs since birth.


Materials and methods:  We performed mutation analysis of candidate genes. In addition, ...

A case of monilethrix caused by novel compound heterozygous mutations in the desmoglein 4 (DSG4) gene is a post from: Skincare

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Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris – A multicenter, randomised, double-blind controlled study

Abstract

Background:  Oral antibiotics in association with a topical retinoid with or without benzoyl peroxide (BPO) are the recommended first-line option in the treatment of moderate to severe acne vulgaris.


Objectives:  To evaluate the efficacy and safety of oral lymecycline 300 mg with adapalene 0.1%-BPO 2.5% (A/BPO) fixed-dose gel in comparison with oral lymecycline 300 mg with a vehicle gel in subjects with moderate to severe acne vulgaris.


Methods:  378 subjects were randomised in a double-blind controlled trial to receive once daily lymecycline with either A/BPO or vehicle for 12 weeks. Evaluations included ...

Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris – A multicenter, randomised, double-blind controlled study is a post from: Skincare

Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris – A multicenter, randomised, double-blind controlled study via BuzzBlazer.com

A microbial aetiology of acne-what is the evidence?

Summary

A microbial aetiology of acne has been suggested since the beginning of the last century. There is considerable evidence, circumstantial at best, which suggests that micro-organisms, particularly Propionibacterium acnes, are important in the pathogenesis of acne vulgaris. However, it is still unclear whether Propionibacterium acnes is actually a causal agent in the development of non-inflamed or inflamed acne lesions. Based on a review of the microbiological data on normal and acne affected skin, we propose that Propionibacterium acnes neither initiates comedogenesis nor does it have a role in the initiation ...

A microbial aetiology of acne-what is the evidence? is a post from: Skincare

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Tumor heterogeneity of mucosal melanomas during treatment with imatinib

Abstract

A comparison of in vitro and in vivo characteristics of tumor cells derived from patients with mucosal melanoma treated with imatinib was performed with respect to KIT mutations.


Three patients with mucosal melanoma were treated with imatinib. Patient derived tumor material was used to establish melanoma cell cultures ex vivo. We evaluated tumor material and cell cultures for KIT protein expression and KIT mutation status. In addition, proliferation assays with melanoma cell cultures were performed with imatinib.


Expression of KIT protein and KIT mutation was shown in two patients that responded to ...

Tumor heterogeneity of mucosal melanomas during treatment with imatinib is a post from: Skincare

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Sorafenib-induced acute localized exanthematous pustulosis in a patient with hepatocellular carcinoma

Sorafenib-induced acute localized exanthematous pustulosis in a patient with hepatocellular carcinoma is a post from: Skincare

Sorafenib-induced acute localized exanthematous pustulosis in a patient with hepatocellular carcinoma is a post from: Skincare

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