A Systematic Review of worldwide incidence of Non-melanoma skin cancer

Abstract

Background:  Non-melanoma skin cancer (NMSC) is the most common cancer affecting Caucasians and the incidence is increasing worldwide. This systematic review brings together 75 studies conducted over the past half decade to look at geographic variations and trends worldwide in NMSC, and specifically incidence data is compared to recent UK cancer registry data.


Materials and Methods:  Following the development of a comprehensive search strategy, an assessment tool was adapted to look at the methodological quality of the eligible studies.


Results:  Most of the studies focused on Caucasian populations in Europe, USA and ...

A Systematic Review of worldwide incidence of Non-melanoma skin cancer is a post from: Skincare

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Role of GSTs in Melanoma Susceptibility: Association with rs1695 GSTP1 Polymorphism.

Summary

Background:  Glutathione S-transferases (GSTs) GSTM1, GSTT1 and GSTP1 are multifunctional enzymes involved in the detoxification of a wide range of reactive oxygen species produced during melanin synthesis and oxidative stress processes.


Objectives:  Single nucleotide polymorphisms (GSTP1) and copy number variants (GSTM1 and GSTT1) may be candidate low-penetrance variants with a role in susceptibility to malignant melanoma (MM).


Methods:  In this case-control study, 562 Spanish sporadic melanoma patients and 338 cancer-free control subjects were included, and the role of these GST polymorphisms was investigated. Genotypes were established by quantitative real time-PCR for GSTM1 ...

Role of GSTs in Melanoma Susceptibility: Association with rs1695 GSTP1 Polymorphism. is a post from: Skincare

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Primary cutaneous nocardiosis caused by Nocardia beijingensis

Primary cutaneous nocardiosis caused by Nocardia beijingensis is a post from: Skincare

Primary cutaneous nocardiosis caused by Nocardia beijingensis is a post from: Skincare

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Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp – a randomized multicentre study

Abstract

Background:  Photodynamic therapy (PDT) is an attractive therapy for non-melanoma skin cancers and actinic keratoses (AKs). Daylight-mediated PDT is a simple and tolerable treatment procedure for PDT. Methyl aminolevulinate (MAL) -PDT is approved for the treatment of thin or non-hyperkeratotic actinic keratoses on the face and scalp. However, thick AK lesions are often treated as well when present in the field-cancerized treatment area.


Objectives:  The aim of the study was in a randomized multicentre study to evaluate efficacy of daylight-mediated PDT for different severity grades of AKs.


Methods:  145 patients with a ...

Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp – a randomized multicentre study is a post from: Skincare

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A case of false negative monochromator phototesting in a patient with chronic actinic dermatitis taking Prednisolone

A case of false negative monochromator phototesting in a patient with chronic actinic dermatitis taking Prednisolone is a post from: Skincare

A case of false negative monochromator phototesting in a patient with chronic actinic dermatitis taking Prednisolone is a post from: Skincare

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Treatment of Anetoderma Occurring After Resolution of Stevens–Johnson Syndrome Using an Ablative 10,600-nm Carbon Dioxide Fractional Laser

Treatment of Anetoderma Occurring After Resolution of Stevens–Johnson Syndrome Using an Ablative 10,600-nm Carbon Dioxide Fractional Laser is a post from: Skincare

Treatment of Anetoderma Occurring After Resolution of Stevens–Johnson Syndrome Using an Ablative 10,600-nm Carbon Dioxide Fractional Laser is a post from: Skincare

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Double Trichophytic Closure with Wavy Two-Layered Closure for Optimal Hair Transplantation Scar

Double Trichophytic Closure with Wavy Two-Layered Closure for Optimal Hair Transplantation Scar is a post from: Skincare

Double Trichophytic Closure with Wavy Two-Layered Closure for Optimal Hair Transplantation Scar is a post from: Skincare

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Epitope mapping of BP230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid

Abstract

Background:  Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterised by circulating autoantibodies against BP180 and BP230. For BP180, the NC16A domain has previously been identified as the main antigenic target in BP, while data about the diagnostic value of epitopes on BP230 were inconclusive.


Objectives:  To identify the most appropriate epitopes on BP230 to be applied in a simple, sensitive, and highly specific ELISA for routine detection of serum autoantibodies.


Methods:  Ten overlapping linear fragments covering the whole length of BP230 were expressed in E. coli. Based on Western blot ...

Epitope mapping of BP230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid is a post from: Skincare

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Interventions for treating oral lichen planus

Abstract

Background:  Oral lichen planus (OLP) is a common chronic inflammatory disease associated with cell-mediated immunological dysfunction. Symptomatic OLP is painful and complete healing is rare.


Objectives. To assess the evidence for the efficacy and safety of treatments for symptomatic OLP.


Methods:  Cochrane Oral Health Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and EMBASE were searched in January 2011 to identify all randomized controlled trials evaluating any intervention for the treatment of symptomatic OLP.


Results:  28 trials were included in this Cochrane review. There is no evidence from 3 ...

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Critical temperature threshold measurement for cold urticaria: a randomised controlled trial of H1-antihistamine up-dosing

Abstract

Background:  Cold urticaria is a rare but severe and potentially lethal condition. It is primarily treated symptomatically with H1-antihistamines. However, patients have a variable response to these drugs and up-to-now it has not been possible to readily predict response to therapy of individual patients.


Objectives:  The aim of this study was to assess the severity of the cold urticaria in naïve patients and the response to therapy of patients treated with increasing doses of an H1-antihistamine by measurement of critical temperature thresholds (CTT) for producing wheals on the forearm.


Methods:  This two ...

Critical temperature threshold measurement for cold urticaria: a randomised controlled trial of H1-antihistamine up-dosing is a post from: Skincare

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The IFN-regulated gene signature is elevated in SCLE and DLE and correlates with CLASI score

Abstract

Background:  There is increased expression of type I interferon (IFN)-regulated proteins in the blood and target tissues of patients with cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE). Patients with SLE have increased IFN-regulated gene expression pointing towards a possible underlying genetic defect.


Objectives:  We measured expression levels of five type I IFN-regulated genes that are highly expressed in SLE in the peripheral blood of patients with CLE and correlated expression levels with cutaneous disease activity.


Methods:  Peripheral blood was obtained from 10 healthy controls and 30 patients with CLE, including ...

The IFN-regulated gene signature is elevated in SCLE and DLE and correlates with CLASI score is a post from: Skincare

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Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma

Abstract

Background:  Topical photodynamic therapy (PDT) is a widely applied treatment for basal cell carcinoma (BCC). PDT-induced immunosuppression leading to ineffective anti-tumour immune responses may be a factor in treatment failure.


Objective:  To examine the impact of topical PDT on leucocyte trafficking following clinical treatment of BCC.


Methods:  Superficial BCC in eight white Caucasian patients were treated with methyl aminolaevulinate (MAL)-PDT. Biopsies for immunohistochemical assessment were taken from BCC pre-PDT, 1h and 24h post-PDT and from untreated healthy skin.


Results:  Treatment of BCC with MAL-PDT produced a rapid neutrophil infiltration, commencing by 1h and ...

Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma is a post from: Skincare

Topical photodynamic therapy significantly reduces epidermal Langerhans cells during clinical treatment of basal cell carcinoma via BuzzBlazer.com

The Pleasurability of Scratching an Itch: A Psychophysical and Topographical Assessment

Abstract

Background:  Scratching an itch is perceived as being pleasurable. However, an analysis of topographical variations in itch intensity, the effectiveness of scratching to provide itch relief and the associated pleasurability has not been performed at different body sites.


Objective:  To examine the role of scratching pleasurability in providing itch relief by investigating whether itch intensity is perceived differently at 3 different sites and to assess a potential correlation between the pleasurability and itch attenuation induced by scratching.


Methods:  Itch was induced on the forearm, ankle and back using cowhage spicules in eighteen ...

The Pleasurability of Scratching an Itch: A Psychophysical and Topographical Assessment is a post from: Skincare

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Five Japanese cases of anti-Dsg1 antibody positive and anti-Dsg3 antibody negative pemphigus with oral lesions

Abstract

Background:  Oral mucosal lesions developed in pemphigus vulgaris, but not in pemphigus foliaceus. This clinical phenomenon is explained by ‘desmoglein (Dsg) compensation theory’. Dsg3 and Dsg1 are major autoantigens for pemphigus vulgaris and pemphigus foliaceus, respectively. Dsg3 is overexpressed and Dsg1 is weakly expressed on the oral mucosa. Thus, on the oral mucosa, suppression of Dsg3 function by anti-Dsg3 autoantibodies is not compensated by weakly expressed Dsg1 in pemphigus vulgaris, while suppression of Dsg1function by anti-Dsg1 autoantibodies is perfectly compensated by richly expressed Dsg3 in pemphigus foliaceus.


Objectives:  We present five ...

Five Japanese cases of anti-Dsg1 antibody positive and anti-Dsg3 antibody negative pemphigus with oral lesions is a post from: Skincare

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Phototherapy in France: Quantitative data from the National Health Insurance register

Phototherapy in France: Quantitative data from the National Health Insurance register is a post from: Skincare

Phototherapy in France: Quantitative data from the National Health Insurance register is a post from: Skincare

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Dermatological emergencies: a comparative study of activity in 2000 and 2010

Abstract

Background and objective  Studies of dermatological emergencies (DE) are few. We evaluated the activity in our DE unit in a 1-month retrospective study and compared the results with a similar study performed in the same department in 2000.


Methods  We reviewed the charts of all outpatients seen in the DE unit in January 2010, collecting data on age, sex, place of residence, referral mode, day and hour of consultation, true emergency or non-emergency, diagnosis and follow-up.


Results  In January 2010, we serviced 605 patients (58% males, mean age 40 ± 21 years), 21% more ...

Dermatological emergencies: a comparative study of activity in 2000 and 2010 is a post from: Skincare

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Validation of self-reported erythema: comparison of self-reports, researcher assessment and objective measurements in sun worshippers and skiers

Abstract

Background  Most epidemiological data of sunburn related to skin cancer have come from self-reporting in diaries and questionnaires. We thought it important to validate the reliability of such data.


Objective  To validate the quality of self-reported erythema by sun worshippers and skiers, and to validate the ability to determine erythema visually compared with objectively measured erythema.


Methods  The skin in a group of sun worshippers in Tenerife and of skiers in Austria was closely monitored over a week. The participants used a diary to record any erythema assessed on different skin sites ...

Validation of self-reported erythema: comparison of self-reports, researcher assessment and objective measurements in sun worshippers and skiers is a post from: Skincare

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Skin fragility and blistering secondary to imatinib

Skin fragility and blistering secondary to imatinib is a post from: Skincare

Skin fragility and blistering secondary to imatinib is a post from: Skincare

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The effects of systemic isotretinoin and antibiotic therapy on the microbial floras in patients with acne vulgaris

Abstract

Background  Although there are several studies about the alteration in skin flora, limited number of reports about changes in the microbial contents and their resistance profile of other body sites in patients treated with isotretinoin for acne vulgaris.


Objectives  The aim of this study was to investigate the effects of systemic isotretinoin and antibiotic therapy on the microbial floras of oropharynx, nose and feces in acne patients.


Methods  Treatment groups of isotretinoin and antibiotics consisting of 20 and 15 patients, respectively were included. Microbiological culture samples were taken at baseline and once ...

The effects of systemic isotretinoin and antibiotic therapy on the microbial floras in patients with acne vulgaris is a post from: Skincare

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Studies on serum 8-hydroxy guanosine (8-OHdG) as reliable biomarker for psoriasis

Abstract

Background  Oxidative stress was implicated in the psoriasis disease development and may damage DNA leading to keratinocytes cell death. No serum biomarker was available for the oxidative DNA damage.


Objectives  To evaluate the 8-OHdG (8-Hydroxy guanosine) as reliable biomarker for the oxidative stress in psoriatic patients with severity.


Methods  A total of 30 patients were considered for the study and graded according to the Psoriasis Area Severity Index (PASI) and 10 healthy controls. Blood was collected under aseptic condition, and serum was separated. Serum 8-OHdG and total antioxidant capacity was measured by ...

Studies on serum 8-hydroxy guanosine (8-OHdG) as reliable biomarker for psoriasis is a post from: Skincare

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